Monday, March 24, 2008

Layer Cake

And if young Nigel says he's happy
He must be happy
He must be happy in his work


Researchers at the University of Arkansas have developed antibodies that bind to amphetamines and ecstasy in rats. The drugs are prevented from reaching brain or heart tissue and are anabolized by the body. The antibodies bond to a range of chemicals with similar structures. One dose may be effective for several days, if it ever makes it to humans.

This would be a great budgeting tool for drug users. Say you tweak and you need to get straight before you go into work. Get an antibody bump, call it tuesday night. Wednesday morning you go to your job. You keep your job because the antibodies keep you sober and want that because you need money for meth. Okay, now you're off work but the antibodies are still active. No use spending money on crank now because you can't get high until friday. You're making money and keeping it. There's no reason to break into a house, purse-snatch, carjack or mug. You may even find you have a surplus of money, which will obviously go into a Roth IRA.

Or you're going to a club. Your friends all drop E but you don't want to. The answer to peer pressure, as every teenager knows, is to give in, and with these antibodies you can do that without any of the annoying pleasure. Also useful for undercover cops that need to prove they're "cool" to murderers, rapists and extortionists. "C'mon, all the hip thugs are doing it. You're not a narc, are you? Dude, he totally snorted it! Dude!"

These antibodies wouldn't be very useful in drug treatment. Rehab is more than "don't do the drugs." People in rehab have already done the drugs and their bodies are expecting certain things. The methadone question becomes either a deal-breaker for many forms of treatment or entirely irrelevant, and it's up to the researchers (and their funding sources) to decide. Amphetamines work because they mimic chemicals which are produced by the human body. An antibody that bonds to ecstasy would likely bond to the natural structures. Drugs used to treat withdrawal symptoms work for the same reason and face the same roadblock. The answer is to develop very, very specific antibodies with narrow target structures. And then develop a separate antibody for each chemical involved. I'll let the University of Arkansas figure out how much that will cost.

There has been research in blocking the effects of many drugs. Mostly it's just the high; few articles mention blood pressure or narcolepsy. As effective cleaners for more drugs are found, we move a little closer to the end of prohibition. Legalized, good-lab-practice drugs sold on the shelf next to InstaSober (tm). And InstaSober (tm) could end up over the counter without schedules I-IV being scratched out. Narcotics users would need available tools to regulate the effects on them; everyone benefits by reducing crime ancillary to drug use. The drug - sorry, pharmaceutical manufacturers then realize they're only penetrating half of the market.

Get you fucked up on saturday for the club, then cleaned up on sunday for church. How hard do you think the drug companies will push for a chance to double-penetrate the consumer?

1 comment:

Anonymous said...

Big Pharma would definitely want their piece